Lesionectomy - Epilepsy Treatments - London Craniofacial Unit

epilepsy

Lesionectomy

Lesionectomy is often recommended when medication alone cannot control seizures and imaging has pinpointed a clear source in the brain. It’s a precise, proven approach that can greatly reduce seizure frequency and help patients regain independence and confidence.

During the procedure, surgeons remove the lesion — a small area of damaged or abnormal brain tissue — that is responsible for triggering seizures or other neurological symptoms. Advanced imaging and monitoring techniques help ensure only the affected area is removed, preserving healthy brain tissue.

At a Glance

Expected Results

Significant reduction or complete control of seizures; improvement in quality of life and daily functioning.

Procedure Time

Typically 3–6 hours, depending on the size and location of the lesion.

Anaesthetic

Performed under general anaesthesia.

Hospital Stay

Usually 3–7 days for monitoring and recovery.

Recovery Time

Most patients need 4–8 weeks for full recovery, with gradual return to normal activities.

Return to Work/School

Usually within 6–8 weeks, depending on recovery progress and type of work.

Follow-up

Regular neurological assessments and imaging to monitor progress and seizure control.

Frequency

One-time procedure; rarely needs repetition if seizures are well controlled.

Risks

As with any brain surgery, there is a small risk of infection, bleeding, or temporary neurological changes, though these are carefully managed.

The Procedure

A lesionectomy is a highly precise form of brain surgery designed to remove a specific area of abnormal tissue that causes seizures or other neurological symptoms.

Before surgery, detailed imaging such as MRI and EEG monitoring is used to accurately identify the lesion’s location and its role in seizure activity. During the operation, the surgeon makes a small opening in the skull to access the affected area. Using advanced microsurgical techniques, the lesion is carefully removed while preserving the surrounding healthy brain tissue.

Throughout the procedure, specialised monitoring ensures critical brain functions—such as movement, speech, and memory—remain protected. Once the lesion is removed, the area is closed and the bone flap is replaced securely.

Patients are then closely monitored in the recovery unit, where most regain alertness within hours. The overall goal is to achieve lasting seizure control while maintaining normal neurological function and quality of life.

Benefits

Seizure Control

Many patients experience a major reduction—or complete stop—in seizures, especially when the lesion is clearly defined and accessible.

Improved Quality of Life

Reduced seizure frequency often allows greater independence, improved concentration, and the ability to resume normal daily activities.

Preservation of Brain Function

Advanced imaging and surgical monitoring help protect vital brain areas, minimising the risk of functional loss.

Reduced Medication Dependence

Successful surgery can allow patients to lower or even discontinue anti-seizure medications over time, under medical supervision.

Long-Term Results

Lesionectomy is typically a one-time procedure that can provide lasting seizure control and improved neurological stability.

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Our Locations - London Craniofacial Unit
Great Ormond Street Hospital (GOSH) Great Ormond Street Hospital (GOSH)

Great Ormond Street Hospital (GOSH)

The home of The London Craniofacial Unit — a world-leading centre for complex Craniofacial and Reconstructive Surgery.
The Portland Hospital The Portland Hospital

The Portland Hospital

Private craniofacial care in a calm, family-focused environment, delivered by the same expert surgical team.
152 Harley Street 152 Harley Street

152 Harley Street

Specialist consultations and advanced diagnostics in London’s leading medical district.
The Wellington Hospital The Wellington Hospital

The Wellington Hospital

Expert craniofacial and reconstructive procedures using the latest surgical techniques and technology.

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The home of The London Craniofacial Unit — a world-leading centre for complex Craniofacial and Reconstructive Surgery.